Flexible, innovative solutions for analysis of the skeleton

Biomechanical testing

mechanical testing2

A number of approaches are available to test the biomechanical properties of bone through skelet.AL or the associated partners.

Micro-indentation:

The BioDent Hfc™ is a reference point indentation device for in-vitro and ex-vivo testing of bone tissue material properties. The BioDent Hfc ™ measures tissue level properties of bone that relate to its overall strength and resistance to fracture.

The BioDent Hfc™ pushes a thin probe into the bone at a fixed force and measures the distance that it travels into the bone material relative to a reference probe at the surface, typically 20–150 µm.

Analysis of the force and distance data provides measures relating to the bone’s resistance to fracturing and its ability to bear loads, without destroying the sample. This enables reference point indentation analysis of bone to be used in conjunction with other methods such as DEXA, CT/µCT and histology.

 

For more information, please contact Dr. Peter Grabowski

bioindentation3bioindentation2Biomech_BioDent_2web

Mechanical testing:

Mechanical testing of bones can be undertaken using the Bose ElectroFocrce 3200 mechanical testing machine. Our instrument is equipped with a 450 N and a 22.5 N load cell and is able to perform a range of mechanical tests including 3 and 4 point bending, tension, compression and fatigue. Customised grips can be designed for non standard shaped samples. We can provide expertise in analysis of mechanical properties such as breaking strength, Youngs modulus and toughness.

 

This is delivered by our associated partners,  Dr Gwen Reilly’s lab

Biomech_6webBiomech_4web

Bone Finite Element models:

MicroCT based Finite Element modelling of bone is a non-destructive way of estimating bone mechanical properties such as bone stiffness and strength. We can provide expertise in generating, calibrating and validating computational models for bone samples extracted from large mammals (trabecular and cortical bone samples) as well as mouse bones (in particular mouse tibia from ex vivo and in vivo scans).

Example of Simulation of bone deformation

For more information please contact Dr. Enrico Dall’Ara.

tibia FE.tifbovine FE.tif
FE model of mouse tibia.
(Courtesy of Dr. Lu)
FE model of Bovine Trabecular bone.
(Courtesy of Y.Chen)